ABSTRACT
This chapter focus on the study of the effects of biologically relevant ions (KCl) on the stability of controlled release systems formed between a host cyclodextrin (β-CD and HP-β-CD) and a guest drug molecule (methylxanthine) aiming to provide accurate information for ulterior drug formulations.
Taylor dispersion technique was used to measure diffusion coefficients for both aqueous ternary mixtures of methylxantine + KCl + water and quaternary mixtures of CD+ methylxantine + KCl + water at temperatures of 298.15 and 310.15 K.
The changes on the behavior diffusion of these multicomponent systems and the coupled flows occurring in the solution, caused by the introduction of ions, were analyzed, and the new association constants for these solutes were estimated.
294An analysis of the molecular interactions is done, explaining the new associations and competition for the CD cavity between the drug molecule and the ions present, leading us to a better understanding of the structure of these systems in aqueous solution and in conditions closer to the in-vivo environment.
