ABSTRACT
This chapter focuses on the optimization of various process and formulation parameters for the development of parenteral dosage form using design of experiments. The researchers encounter complex technical challenges during formulation development, which makes it imperative to use an effective methodology for formulation development. The pharmaceutical convention, however, is to use the term parenteral for those medicines that are administered by means of an injection. Parenteral products are the mainstay of treatment for hospitalized patients. The pharmaceutical Parenteral preparations, containing the active pharmaceutical ingredients, and other appropriate excipients, can be administered either as a liquid in the form of solutions, emulsions or suspensions or as solid products. The advent of biotechnology has further increased the demand for the parenteral route of delivery for biologicals as the biomolecules, peptides, and proteins cannot be readily administered by any other route due to bioavailability and stability issues.
