ABSTRACT
Delayed lactation is defined as lactation established beyond 72 hours postpartum. It is caused due to abnormal lactogenesis in stage 2 and 3. The synthesis of milk protein is influenced by insulin and prolactin. Insulin/IGF II influences the cell signaling pathways and initiates lactogenesis. INSR-A and INSR-B play a crucial role in breast development during pregnancy and lactogenesis. Lifestyle changes lead to obesity, which results in the development of insulin resistance. Insulin resistance leads to delayed lactogenesis and lactation failure. Clinical and translational research is needed to address the issue. Public health strategies should be designed to modify lifestyles, reduce obesity, and induce exclusive breastfeeding between 0 and 6 months of age of the newborn.
