This chapter aims to demonstrate that agriculture, and specifically crop nutrition, is a key entry point for positive human health outcomes. Potassium has been selected for this review, because it is a mineral element that originates in the soil and the K nutrition of plants and humans largely rely on the transition of K from the soil to the plants and human via the food chain. The initial search focused on individual components, K, and soil health; K and plant health; and K and human health. Quantitative soil health indexes have yet to be applied to potato-production areas. Soil health has been declining along with potato productivity. Comprehensive data sets capturing the fates of nutrients and other quality parameters offer promise to deepen our understanding of how soil, plant, and human health interact to meet the energy and nutritional needs of humans to create desired health outcomes in system.