ABSTRACT
Microneedling is a relatively new minimally invasive procedure involving superficial and controlled puncturing of the skin by rolling with miniature fine needles. Microneedle could be a single or an array of micron-sized needles that can penetrate the epidermis and upper dermal layer of the skin. The various cosmetic uses of microneedles include acne vulgaris, acne scars, skin rejuvenation, and hair growth. Micropunctures are created using microneedles which produce controlled skin injury without actually damaging the epidermis. The inflammatory phase is characterized by increased capillary permeability and cell migration into the wound site. The proliferative phase begins after the primary inflammatory responses to the injury. The main and leading events that happen during this phase include re-epithelialization, angiogenesis, and fibroplasia. Wound contraction starts soon after dermal tissue injury and peaks in the 2 weeks after the initial insult.
