ABSTRACT
The design of an asymmetric catalytic reaction is based on a very complex approach, considering the interplay between metal, chiral ligand, substrate and reagent in a strictly determined environment and under singular conditions. This set-up is finally summarized under the term “reaction conditions”. One of the most important factors for the success of any chemical reaction is the proper choice of the solvent in dependence on the catalyst. This holds also for asymmetric catalysis. Besides classical solvents also unusual solvents like fluorous solvents, ionic liquid, supercritical fluids and water will be evaluated always in relation to the chiral ligands and catalysts used. Benefits of unusual solvent and problems will be critically analyzed.
