ABSTRACT
In sequential Interpenetrating Polymer Networks (IPNs), the first cross-linked polymer network is swollen by all the precursors of the second polymer that is polymerized and/or cross-linked afterward. The pertinent role of polymers in progressing drug delivery technologies to great heights is evident due to their potential to provide controlled bioactive release, either as sustained levels over prolonged periods, pulsatile or cyclic dosage, or tunable release, of both hydrophilic and hydrophobic drugs. Various IPN composites composed of alginate and synthetic polymers containing carboxylic groups, with novel properties like super-porous, electrical sensitivity, drug-controlled release, and multi-responsive nature, have been designed. Controlled drug release technology emerged during the 1980s as a commercial approach to expand the available possibilities of administering pharmaceutical therapies. The aim of the increasingly intricate design of controlled release polymeric systems is the enhancement of drug therapy. Controlled release of chlorpheniramine maleate drug through sodium alginate-g-methylmethacrylate IPN beads has been reported.
