ABSTRACT
The solubility of alginate in a solvent is determined by the status of its carboxylic group while being in the solvent, the pH as well as the ionic strength. In many cases, alginate has been chemically modified in order to fit a desired property for wound dressing applications. The resulting alginamine has amphiphilic characteristics that increase its potential to be used in many applications, especially biomedical applications. Degradation of alginate is influenced by the molecular weight of the polymer. Typically, alginate with high molecular weight has a lower degradation rate. G. T. Nguyen et al. proposed a composite system based on oxidized alginate, gelatin, and biphasic calcium phosphate for bone regeneration. M. K. Ghahramanpoor et al. have applied the esterification reaction of octadecyl chains to alginate in order to enhance the alginate overall mechanical and swelling properties in the physiological conditions as well as to render the polymer into more hydrophobic.
