ABSTRACT
This chapter focuses on structure-activity considerations associated with receptor targeting in the lung. Future directions for the more effective utilization of monoclonal antibodies as drug targeting agents must focus on a more rational design of the antibody-drug conjugate. Chemical entities that could be incorporated into the conjugate structure that may influence its biodistribution should also be investigated. Bioadhesion targeting is, therefore, a combination of biophysical trapping and biochemical adherence. The pore radius of paracellular channels between epithelial cells is about 1 nm, which is a quarter of the pore radius found between the adjacent endothelial cells. The drawback to using the antihistamines included their marked individual variation in response between patients, specificity of histamine receptor antagonism, and dose and route given. Asthma is characterized by inflammation of the lung; thus, the most prescribed agents to date are the glucocorticoids, due to their widespread anti-inflammatory properties.
