ABSTRACT
This chapter examines the process of interpreting metabolic models with the goal of estimating intake from bioassay data. Ideally, radiological indicators such as contamination levels, airborne concentrations, worker tasks and location, and radionuclide inventories should substantiate intake estimates. Sensitivity requirements are therefore based on both the dosimetric significance and the retention of the radionuclide. Sensitivity requirements may need to be reduced if exposure to multiple radionuclides is possible or if external exposure is expected. Interpretation of incremental fecal samples is more problematic. Consequently, multiple bioassay measurements connected with the same exposure yield different intake estimates. In addition to demonstrating the usefulness of harmonizing bioassay data, the case illustrates the importance of integrating workplace information into exposure assessments. Intake assessment requires an understanding of the transfer, retention, and excretion of radioactive material taken into the body. Sensitivity requirements are therefore based on both the dosimetric significance and the retention of the radionuclide.
