ABSTRACT
MicroRNAs are important regulators with various roles in differentiation and development including the complex process of hematopoeisis. MicroRNAs have been implicated in the development and progression of various cancers including hematologic malignancies. Many of these are also linked to normal hematopoeisis. MicroRNA profiling technologies have evolved over time and the current state of the art (massively parallel microRNA sequencing, or miRNA-seq) enables deep profiling of the entire microRNAome. MiRNA-seq profiles can differentiate patient biopsies from clinically distinct subtypes of diffuse large B-cell lymphoma. The combination of miRNA-seq and transcriptome sequencing (RNA-seq) will offer the potential to identify novel miRNA-target interactions as well as polymorphisms and mutations (in genes or rnicoRNAs) that alter microRNA targeting during the development of cancer.
