ABSTRACT
This chapter discusses the effect of hyperthermia alone on the tumor will be discussed together with the effect of some modifiers on thermal effect of the tumor. Tumor response to hyperthermia depends on temperature and duration of treatment. The tumor growth time assay is probably most commonly used for studying the tumor response to hyperthermia. Tumor response to hyperthermia depends on the treatment temperature and the duration of the treatment. Presumably, reduced tumor tissue pH enhances the tumor response to hyperthermia. Although the administration of ammonium chloride or sodium bicarbonate has been proven to reduce tumor tissue pH, these methods have been investigated as a method to enhance the tumor response to hyperthermia. The studies can be classified into three categories; the effect of whole-body hyperthermia on the host immune reaction, the effect of heat-killed tumor cells on the proliferative tumor cells, and the effect of non-specific immune stimulant at elevated temperatures on the tumor tissue.
