ABSTRACT
Nanomedicines are a new class of pharmaceutical in which the active is presented in the form of a nanoparticle. Nanomedicines are prepared from various water insoluble polymers, self assembled low molecular weight amphiphiles and self assembled amphiphilic polymers. Nanomedicines are prepared from the aggregating polymers by loading the drug on to the nanoparticles. Cyclosporine A — quaternary ammonium cetyl poly(ethylenimine) nanomedicines withstand the desolvation of cyclosporine A at elevated temperature, a process which normally results in drug precipitation. The self assembly of soluble polymers into nanomedicines is easily controlled via the polymer chemistry and various nanosystems may be produced from a single polymer backbone with the nature of the self assembly largely dependent on the levels of alkylation/acylation and hydrophilic substitution. In a series of experiments, the polymers were found to act by increasing the dissolution of the drug and promoting transcellular transport.
