ABSTRACT
This chapter describes new biomaterial led approaches to immobilization, maintenance, programming and promotion of desirable stem cell responses while regenerating clinically acceptable human tissues. It discusses efforts to enhance survivability of human cell transplantation inside protective devices. In biologic environment the synthesized biomatrix evolves in real-time to meet the demands and optimisations of adaptive growth and regeneration of human tissues. Biomaterial structures that are designed and built by human cells and their cellular components are only just being realized and are an important aim for future biomaterials for clinical applications. The use of modular self-assembling biomaterials for making equivalent structures to natural archetypes is a new approach. It simulates more accurately the way in which natural structures are constructed. Allowing human progenitor cells to re-assemble their matrix environment using tailored synthetic biomaterial “building blocks” is a new concept. The approach promises a new class of biomaterials designed and constructed by biology.
