ABSTRACT
The probable mechanism of action for all of the stable N-halamines involves direct contact of the microorganism with the combined N-halamine, followed by donation of a Cl+ or Br+ species to a receptor site within the cell, causing oxidation, and subsequent cell inactivation. Work in the laboratories at Auburn University has established a novel class of heterocyclic organic compounds termed N-halamines that have been demonstrated to be excellent antimicrobial materials for a broad variety of applications. First, a series of N-halamine compounds in the classes oxazolidinones and imidazolidinones were synthesized and tested. These compounds, some of which are being commercially developed, are state-of-the-art disinfectants for applications requiring water solubility. Second, a new insoluble N-halamine polymer, which is a derivative of poly(styrene-hydantoin), was prepared. The unchlorinated polymer latex compounds were coated onto various substrate surfaces. Polymer coatings should have considerable commercial potential.
