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      Chapter

      Risk Characterization
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      Chapter

      Risk Characterization

      DOI link for Risk Characterization

      Risk Characterization book

      Risk Characterization

      DOI link for Risk Characterization

      Risk Characterization book

      ByRoy E. Albert
      BookRISK ASSESSMENT and INDOOR AIR QUALITY

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      Edition 1st Edition
      First Published 1999
      Imprint CRC Press
      Pages 12
      eBook ISBN 9780429138997
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      ABSTRACT

      In the 15th century, Theophrastus Bombastus Hohenheim announced that everything is toxic; it is just a matter of dose. This is the one thing in toxicology that almost everyone agrees with. It follows, therefore, that every agent, within reason, ought to have some form of control whether by a recommendation on intake limits or an enforceable regulatory exposure standard. The Environmental Protection Agency (EPA) began risk assessment in the cancer area requiring the initial assessment to indicate whether there was enough basis to launch a full-scale investigation of an agent as a carcinogen. The EPA advocated the use of several mathematical extrapolation models, although it was realized that the cornerstone of quantitative risk assessment would become the linear nonthreshold dose-response model. Risk characterization is the component of the risk assessment that produces both the population and the individual risk estimates. It is obtained by multiplying the dose by the probability of response as derived from a dose–response model.

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