ABSTRACT
The study of drug disposition in physiological compartments is traditionally referred to as pharmacokinetics. Toxicokinetics includes the more appropriate study of exogenous compounds , the adverse effects associated with their concentrations, their passage through the physiological compartments, and the chemicals’ ultimate fate. Clinical applications of kinetics, and the phenomena of absorption, distribution, metabolism, and elimination, are useful in the monitoring of pharmacological and toxicological activity of drugs and chemicals. The membrane consists of phospholipid polar heads, glycolipids, and integral proteins organized toward the periphery of the membrane, and the nonpolar tails and cholesterol directed inward. The rest of the membrane is interspersed with transmembrane channel proteins and other intrinsic proteins. The vestibule of the nasal cavity and nasopharynx is covered by olfactory epithelium. This mucous membrane lining consists of an extensive network of capillaries and pseudostratified columnar epithelium interspersed with goblet cells.
