ABSTRACT
CAR coxsackie and adenovirus receptor CD cellular diff erentiation number DAF decay accelerating factor ESAM endothelial cell-selective adhesion molecule fMLP formyl-methionyl-leucyl-phenylalanine HXA3 hepoxilin A3 ICAM-1 intracellular adhesion molecule 1 IL interleukin JAM junctional adhesion molecules LFA lymphocyte-associated function antigen LPS lipopolysaccharide LT leukotriene Mac macrophage antigen neutrophil polymorphonuclear leukocyte PECAM-1 platelet adhesion molecule 1 PSGL P-selectin glycoprotein ligand TNF tumor necrosis factor VCAM -1 vascular cell adhesion molecule 1 VLA very late antigen
1. Neutrophils are fi rst captured to the wall of the blood vessel. 2. Once captured, neutrophils roll along the vessel wall (mediated by
selectins) until they become arrested (mediated by β2 integrins). 3. Neutrophils then undergo adhesion strengthening and intracellular
crawling. 4. Neutrophils diapedes across the endothelium, travel through the
extracellular matrix, and arrive at the base of the tissue. 5. Neutrophils bind to the basolateral surface of epithelial cells and
transmigrate across the epithelium. 6. Once the neutrophils have completely transmigrated across the epithelium
they adhere to the epithelial surface.
