ABSTRACT
HCAECs human coronary artery endothelial cells HDMECs human dermal microvascular endothelial cells HUVECs human umbilical vein endothelial cells ICAM-1 intercellular adhesion molecule 1 LDL low-density lipoprotein LOX-1 lectin-like oxidized LDL receptor 1 MM-LDL minimally modifi ed/oxidized low-density lipoprotein NF-κB nuclear factor-kappaB Ox-LDL oxidized low-density lipoprotein Ox-PAPC oxidized1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine PAPC 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine PKA protein kinase A PKB protein kinase B PKC protein kinase C ROS reactive oxygen species SR-BI scavenger receptor BI SRCL scavenger receptor with C-type lectin SREC-I scavenger receptor expressed on endothelial cell I SR-PSOX scavenger receptor for phosphatidylserine and oxidized lipoprotein TLR toll-like receptor VCAM-1 vascular cell adhesion molecule 1 X-LDL xanthoma lesion-oxidized low-density lipoprotein
Th e following are the basic facts about low-density lipoprotein that is a fraction of the total serum lipids. Th is lipoprotein is associated with an increased risk of atherosclerosis and cutaneous xanthomas. 1. A lipoprotein is a biochemical assembly that contains lipids and proteins. 2. Lipoproteins are classifi ed by density: high-density lipoprotein, low-
density lipoprotein, intermediate-density lipoprotein, very low-density lipoprotein, and chylomicrons.
