ABSTRACT
In brain ischemia, stimulation by various infl ammatory cytokines increases the expression of adhesion molecules, which enhances interaction between leukocytes and vascular endothelial cells. Th ough this mechanism is considered important to brain infarction, in particular cerebral small-vessel disease (SVD), it has not yet been studied in detail. In this chapter, we primarily discuss the association between brain infarction and microcirculation dysfunction in cerebral small vessels at the acute and chronic phage.
