ABSTRACT
B cells of pancreatic Langerhans produce insulin hormone and tumors from these cells are called as insulinoma. These tumors occur exclusively in the pancreas and are a neuroendocrine tumor. Insulinoma is small, often benign and rare tumor with incidence of four in one million persons. They can occur as sporadic or a part of familial syndromes (multiple endocrine neoplasia type 1). Patients present with neuroglycopenic, neurogenic symptoms or combination of both. The diagnosis is biochemical but difficult many times. After biochemical diagnosis, imaging studies are required to localize the tumor. The treatment is surgical excision and the goal of surgical excision is a complete excision will give the patient cure.
