ABSTRACT
High blood pressure (BP) remains a leading cause of mortality and cardiovascular and renal complications despite all the efforts made during the last decades to improve blood pressure (BP) control. Hypertension is a multifactorial disease caused in the majority of cases by dysregulations of several mechanisms implicated in the regulation of BP. There are several physiological, pharmacological and clinical reasons to the use of single-pill combinations in the management of hypertension. There is a very large choice of single-pill combinations associating two antihypertensive drug classes available on the market. Dual combinations containing an renal artery stenosis blocker and a diuretic belong to the most frequently used associations in the management of hypertension. About 30-40% of patients with hypertension will need more than two drugs to achieve BP targets. Australian investigators have recently developed the concept of the quadpill, which consists of combining four active antihypertensive substances at very low dose in a single pill.
