ABSTRACT
A series of some novel 2,4-dimethoxy-6-(piperazin-1-yl)-1,3,5-triazine aryl ureido/aryl amido derivatives of biological interest were prepared and screened for their pro-inflammatory cytokines (TNF-α and IL-6) and antimicrobial activity. Among all the series of compounds screened, many compounds were found to have promising anti-inflammatory activity (up to 65-73% TNF-κ and 73-85% IL-6 inhibitory activity) at concentration of 10 μm with reference to standard dexamethasone (75% TNF-α and 84% IL-6 inhibitory activities at 1 μM) while the similar compounds found to be potent antimicrobial agent showing even 2-2.5-fold more potency than that of standard ciprofloxacin and miconazole at the same MIC value of 10 μ/mL.
