ABSTRACT
Bone as a skeletal armour developed as a biological and physical defence against the predaceous habits of the eurypterids, largely feeding on the early vertebrate “bony fishes” at the evolutionary beginning of the vertebrates. It seems likely that the eurypterids’ aggressive feeding on the evolutionary beginning of the vertebrates “was primarily responsible for the development of the vertebrate bony armour”. Columnar condensations of chondroblastic cells are to be found in the pleiotropic uniqueness of the cartilaginous growth plate, a fundamental compartmentalized biological system of growth that masterminds the tri-dimensional growth of the mammalian axial skeleton that forms through endochondral osteogenesis via the cartilage anlage. Primarily, membranous osteogenesis originates after the induction of mesenchymal condensations populated by contiguous osteoblasts that later continuously secrete bone matrix as yet to be mineralized, or osteoid, around invading and supporting central blood vessels. In the bone matrix, molecular signals are in solution, interacting with the insoluble signal of the extracellular matrix.
