This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book aims to discuss some of the ongoing key innovations in communications and nanotechnologies involved in the emerging Internet of Nano-Things (IoNT) paradigm, which is setting the basis for the future of smart wearable devices and approaches. It explores achievements in the area of wearable and wireless body-area networks and point to existing challenges that the research and industrial communities are facing in trying to extend IoNT paradigm to a broader spectrum of related devices and communication protocols. The book investigates several up-to-date communication protocols and design aspects that can dramatically affect performance. It focuses on the challenges introduced and strategies to be considered while dealing with the IoNT issues. The book investigates a new routing technique for the IoNT paradigm in terms of energy consumption and hop counts.