ABSTRACT
The cadmium concentrations in bone are much lower than the concentrations in several other tissues. In animal experiments cadmium effects on bones, in the form of decreased mineral content, were reported many years ago by C. Ceresa. The role of vitamin D in calcium metabolism has been extensively reviewed by several authors. F. Tsuruki and co-workers, using the everted gut sac technique in rats, showed a cadmium-induced inhibition of vitamin D-stimulated calcium transport in vitro. Cases of bone effects among people exposed to cadmium in the general environment have only been reported from Japan. A. Ishizaki and co-workers first reported histopathological changes in bone induced by cadmium in male and female rats exposed to cadmium and a low calcium diet for 24 weeks. A total of 55 cases of various bone effects following occupational cadmium exposure have been reported. The studies on effects on collagen metabolism topic were carried out on cadmium-exposed humans and not on animals.
