ABSTRACT
Parenteral administration of cadmium may give rise to sarcomas at the injection site and interstitial cell tumors of the testis. Magnesium and calcium were administered to different subgroups of rats via the diet or via repeated subcutaneous injections. Rats were given injections of cadmium chloride at four different sites: tissues derived from ectoderm, endoderm, epithelial mesoderm, or mesenchymal mesoderm. L. A. Poirier et al examined the influence of calcium and magnesium on the carcinogenicity of cadmium chloride in rats. A study has shown that inhalation of cadmium chloride aerosol has a strong carcinogenic effect in rats. In 1984, C. L. Sanders and J. A. Mahaffey reported no evidence of lung cancer in rats given intratracheal instillations of cadmium oxide. Mutagenic effects of cadmium, as revealed by chromosome changes, have mainly been seen in cells exposed to cadmium sulfate, cadmium sulfide, and to cadmium chloride. Conflicting results have been reported for humans exposed to cadmium.
