ABSTRACT
Over the past decades, many peoples were affected by oral cancer, namely lip, salivary glands, buccal mucosa, gingiva/alveolar ridge, soft palate, floor of the mouth, back of the tongue, tonsils, throat and maxillary antrum. The World Health Organization reported that each year 6,57,000 new cases of oral and oropharynx cancer patients were diagnosed and around 3,30,000 deaths were predicted worldwide. The occupation and atmospheric pollution are the prevalent reasons for developing oral cancer as compared to others. Electrospinning is one of the versatile techniques to support various surgical and rehabilitation treatments due to its interconnected porous structure which mimics the extracellular matrix protein structure. The anti-cancer drug 5-Fluorouracil was incorporated into Poly (L-Lactide) and the surface was modified into hydrophilic nature by electrospinning process for oral cancer treatment. The surface morphology, pore distribution, average pore diameter, hydrophilic, crystalline nature and in-vitro drug release studies of the electrospun 5-Fluorouracil incorporated Poly (L-Lactide) nanofibrous scaffold were discussed.
