ABSTRACT
Hyperthermia may become an important modality in the treatment of cancer. The mature blood cells can be recognized on morphological or functional grounds; erythrocytes are an example that comes to mind readily, because of their content of hemoglobin and the fact that they lack a nucleus. The “myeloid stem cell”, operationally defines as the “colony–forming unit–spleen” is originally describes by J. E. Till and E. A. McCulloch by virtue of the fact that these cells, when injected into lethally irradiated murine hosts, caused the growth of colonies of hematopoietic cells on the host spleens. An intermediate stage of development, designated Burst-forming unit-erythroid II, has describes from the culture of both murine and human hematopoietic tissue. The lack of a consensus on the heat sensitivities of different hematopoietic populations is at least partly due to a lack of standardized procedures for carrying out the experiments.
