ABSTRACT
Cannabis contains many biologically active ingredients. We present an approach to the categorization of these ingredients developed from our observations of a cannabis-prevalent community. Our approach involves a linguistic analysis of aroma terms used by the community as they describe distinct cannabis effects. Univariate and multivariate analyses are employed to determine how specific terpenes correspond to these aromatic designations. The results suggest that both terpenoid content patterns and patches of loss may contribute to aroma category assignments. These aroma categorizations are an opportunity to identify relationships between the multiple active cannabis constituents and their effects. We tracked the aroma categories over time, recording responses from smoked or vaporized cannabis flower users. The responses indicate a seasonal availability of aroma categories, which are likely due to storage and packaging capabilities, as well as market forces. There is also some indication of gender-based preferences in aroma category use patterns. Further analysis revealed that the cannabis β-pinene:limonene ratio clearly distinguishes one of two aroma groups. The ratios persist through multiple datasets acquired from different laboratories. We propose that this ratio is an ideal biomarker, which may distinguish the commonly described uplifting vs sedative effects of inhaled cannabis smoke or vapor. Thus, the organoleptic description of cannabis provides a framework for understanding universal concepts underlying the pharmacology of cannabis.
