ABSTRACT
The toxicity of chemotherapy, immune checkpoint inhibitors, and the remote effects of cancer on the peripheral nervous system are a huge problem for many persons worldwide. In this chapter, the authors describe an approach to understanding the effects of chemotherapy, the novel ICI, and cancer on the PNS. Chemotherapy-induced peripheral neuropathy (CIPN) is a common (nearly 70% of patients), underdiagnosed, underreported, and undertreated problem in cancer patients. The pathophysiology, the long-term prognosis, and how best to prevent and treat CIPN are still a work in progress. The best intervention for patients still on chemotherapy is once patients conclude treatment, pharmacotherapy and integrative medicine take center stage. SSN is associated with small-cell lung cancer with circulating anti-Hu antibodies, and much less frequently with Hodgkin lymphoma, breast, prostate, and colon cancer.
