ABSTRACT
Modern cancer medicine depends highly on the detection of selective biomarkers to support therapeutic regimens, which have also become more and more precise. Chronic myeloid leukemia had a paradigmatic role in demonstrating the correlation between an accurate molecular assessment and patient prognosis or treatment success. Leukemia is a clonal disorder originated in the bone marrow during hematopoiesis and is characterized by the unregulated proliferation of poorly differentiated white blood cells. Prognosis and treatment of the disease depend highly on the type of leukemia, the extent of the disease, age, and patient history. Most patients are treated with chemotherapy or targeted therapy, although a small portion ultimately undergoes radiation therapy and/or bone marrow transplantation. Light absorption, scattering, and emission are enhanced in gold nanoparticles due to the interaction of light with the free electrons in the particles. The oscillation of free electrons in resonance with the electromagnetic field is called surface plasmon resonance.
