ABSTRACT
Infectious diseases are among the main problems of modern medicine and mortality throughout the world. The WHO and CDC have expressed serious concerns about the continuing increase in multi-drug resistance among microorganisms. The crisis associated with antibiotic resistance remains one of the most urgent problems in global public health. It is known that the major routes of resistance to antibiotics include enzymatic modification or degradation of the antibiotic molecule, the efflux of antibiotics from the bacterial cell through efflux pumps, and change of the target antibiotic, which prevents antibiotic binding and thus leads to loss of its activity (Kapoor et al. 2017). These different mechanisms show that different approaches to this problem are needed. However, the high prevalence of resistant microbes makes this problem extremely difficult to solve and requires innovative approaches.
