ABSTRACT
This chapter discusses the cells and mechanisms involved in cellular immunity. It begins by describing how T cells recognize peptides presented in the context of major histocompatibility complex molecules on the surface of antigen presenting cells (APCs). Then, it reviews the elements that modulate the interaction between T cells and APCs, as well as the factors involved in shaping the resulting T-cell response. A description of the signaling events associated with T-cell activation is provided, followed by a portrayal of the differentiation processes of CD4 and CD8 T cells. The multiple subpopulations of effector T cells and their biological properties are discussed in detail. Finally, the cellular mechanisms underlying immune memory and immune regulation are presented.
