ABSTRACT
Since the end of the last century when J. Wolff postulated that bone remodels in such a way that it attains maximum resistance to applied forces, a large body of evidence has established the link between mechanical loading and elevated rates of remodeling. The basis of orthodontic tooth movement is simple, that teeth move through bone in a response to an applied mechanical force. This involves bone remodeling. Although the resistance of cementum to resorption is not directly relevant to prostaglandins (PGs), it is an intriguing phenomenon, and like the normal resistance of cartilage to vascularization and osteoclastic resorption, it could tells a lot about the regulation of resorption. The involvement of PGs in orthodontic tooth movement was first suggested by Z. Davidovitch and J. L. Shanfeld as a possible explanation of the changes in cyclic nucleotides they had observed.
