Epidemiological analysis normally requires some consideration of socioeconomic and behavioral risk factors: for example, those related to occupation, gender, religious preference, income, or ethnicity. Those concerned with control of disease must also concern themselves with human factors that interfere with or contribute favorably to effective control. This chapter, therefore, recapitulates and pulls together some of the points in the general literature on arboviral infection and disease. It broadly surveys the kinds of behavioral, cultural, social, psychological, and economic factors that need to be kept in mind in epidemiological research on these viral agents and in control of the diseases with which they are associated. Arbovirus epidemiology has given much more attention to behavioral, cultural, and socioeconomic determinants relating to those at risk to prevent disease or control transmission. In addition to personal protection many people in areas of endemic arbovirus infection make some effort to control vector breeding and thus to reduce the risk of biting contact.