ABSTRACT
This chapter examines psoriatic sera for the presence of an anti-IgG activity. It presents a hypothetical view of the significance of these humoral disorders in psoriasis. Serum IgA, IgG, and IgM estimation was performed by the radial immunodiffusion technique, using commercially available plates. Anti-IgG factors were investigated in sera from 50 patients with psoriasis and 50 age-matched subjects without psoriasis or any rheumatic disease. The presence of anti-IgG antibodies has been reported in many other diseases including those due to autoimmune mechanisms. Such an anti-IgG activity consistent with rheumatoid factor of various classes were also demonstrated in psoriatic lesions by Hans-Kristian Krogh and Olav Tonder. Comparison of serum immunoglobulins levels in psoriasis and eczema shows a significant difference for IgA and IgM. The presence of anti-IgG antibodies has been reported in many other diseases including those due to autoimmune mechanisms.
