ABSTRACT
Immunoelectrophoretic analysis revealed the presence of albumin, gamma globulins, transferrin, antitrypsin, haptoglobin, orosomucoid, and a number of other minor unidentified serum proteins. From clinical observations as well as abundant experimental investigations psoriasis has emerged as an extremely multifaceted disease. Considerable amounts of serum proteins have been detected in aequous eluates from psoriatic scales. The process of leukocytic emigration from dilated, engorged blood vessels and the invasion of these cells into the epidermal compartment as a result of chemotactic attraction can be observed most impressively in pustular psoriasis. In initial psoriasis focal changes comprising sometimes only one or a few adjacent papillae together with the overlying epidermis can be observed. In initial psoriasis both the pathogenic significance and the origin of inflammation is much more difficult to interpret. Histomorphology reveals a striking resemblance to a delayed-type hypersensitivity reaction as seen in allergic contact dermatitis.
