ABSTRACT
In 1966, H. Langhof and H. Muller demonstrated that ultrafiltered homogenates of psoriasis scales showed chemotactic activity for human peripheral blood leukocytes in plasma, using photomicrographic technique. The chemotactic activity in various chemotactic agents were characterized by gel filtration on Sephadex® G-200. Weak chemotactic activity was observed in a multiphasic pattern. Since psoriasis scales contain serum protein as a consequence of an exudative process, serum obtained from a patient with psoriasis vulgaris was studied similarly. Since bacterial chemotactic factors combining with proteins are retained in the crude extract even after dialysis, it is quite probable that their presence influence these results. The chemotactic activity located near the cytochrome C marker is characteristically high in the psoriasis scale extract. Moderate activity was noted in fractions containing bovine serum albumin in addition to low molecular weight fractions.
