ABSTRACT
Many researchers are of the view that faulty control of epidermopoiesis, which give rise to such a high degree of acanthosis of the rete ridges and to incomplete keratinization, plays a main role in the pathogenesis of psoriatic lesions. The migrating leukocytes are mononuclear cells and Polymorphonuclear leukocytes (PMNs) in ordinary psoriatic lesions although the former predominate in early lesions and the latter in the acute exudative or pustular forms. In actual psoriatic lesions PMNs migrate toward the stratum corneum and accumulate beneath it. Chemotactic factors are expected to exert their activity for migrating cells only when there is an increasing chemical gradient. Thus PMNs moving through the Millipore® filter were examined by reversing the concentration of the chemotactic factor. Corresponding to the macroscopic erythematous response, emigration of PMNs was observed in the upper and mid dermis; 30 to 60 min after the intradermal injection of PLF, scattered PMNs were found in a perivascular pattern in the dermis.
