ABSTRACT
Tin fluorouracil is known that enhancement of dietary tin suppresses oncogenesis in rats, mice, and other mammals. Tin fluorouracils shrink solid tumors in clinical use for this purpose. In tumor suppression, using a tin steroid as the therapeutic agent, it is believed that the steroid head enables penetration of the phospholipid/protein membrane and attack of the mitotic peripheral tumor cells. Dry ethanol and chloroform are found to be good solvents for organotins as well as the steroids used as starting compounds in the synthesis of tin-steroids. The bulky aromatic rings of organotins interfere with the reaction sites of steroids causing steric hindrance. Cholic acid can be taken as an ideal compound to vary the attachment site of tin or the steroid ring system by first blocking the unhindered sites. In the cholic acid molecule, there are three hydroxyl groups and one carboxyl group.
