ABSTRACT
Very few experimental studies keyed to carcinogenicity have been concluded with organotins. Considerable interest has been expressed in the role, if any, of trace metals in carcinogenicity. Tin content of tumors is dramatically lower than would be expected, based on homologous nonpathogenic tissue in the cancer victim. Lowered incidence of tumor formation in rodents exposed continuously to relatively high organic or inorganic tin in their diets was indicative, when coupled with other evidence reported supra, that the body accepts xenobiotic tin, processes it into a useable anticarcinogenic or antioncogenic form, wherein it functions in repression of cancer. A logical approach would be first to discover the site of tin accumulation in the mammalian body in the hope that this would provide a key to the nature of the anticarcinogenic tin entity. Consequently, the initial experimental studies were undertaken.
