ABSTRACT

Tin is found in human and mouse organs, as well as in many other animals. The hyperplasia was sufficiently severe to compress the thymus gland, but this seems to be a commonplace reaction to a foreign body rather than a reaction to tin. The animals fed the compounds showed no enhanced tumor growth and a decrease in malignant tumors. Tissues were extirpated from the mice, washed in a saline solution, rinsed with distilled water, dried with a paper towel, and weighed without further treatment. The analysis for tin in the organs of the animals on the supplement was slightly higher than the controls but again, within the standard deviation of the group. In a normal, healthy human or mouse the tin level in the blood is detectable levels by the methods used in these experiments. Since some structural forms serve as antitumoral agents, the Organotin compounds, especially the dialkyl and trialkyl compounds, have very select toxicity to malignant cells.