ABSTRACT
The production of human serum albumin nanoparticles requires slight modifications of the described procedure for gelatin nanoparticles. A very small amount of radioactivity, probably degradation products, penetrates through the cornea and can be found in the aqueous humor. Inflammation of the tissues increases the adherence of the nanoparticles by 3 to 5 times. The binding of doxorubicin to polyisobutylcyanoacrylate nanoparticles also decreased their toxicity significantly in comparison to free drug. Ampicillin and gentamycin were bound to polyisobutylcyanoacrylate and polyisohex-ylcyanoacrylate nanoparticles by polymerization of the cyanoacrylates in the presence of the drugs. Since nanoparticles accumulate in the reticuloendothelial system, they hold promise as drug carriers for the treatment of leishmaniasis. Since nanoparticles adhere to inflamed ocular tissue at a level that is 4 times higher than in healthy tissue, these particles also hold promise for the targeting of anti-inflammatory drugs to inflamed eyes.
