ABSTRACT
This chapter presents cumulative data which deals with the existence of more than one dopamine receptor in mammals. In addition, evidence is presented for the existence of two antagonistic dopamine-functional expressions in the human. This fact, along with the disclosure of new dopamine (DA) agonistic and antagonistic drugs, should prove useful in the management of diseases in which these drugs have proven to be good therapeutic tools. Cumulative data dealing with the existence of more than one DA receptor in mammals are fast increasing. In addition, evidence for the existence of two antagonistic DA-functional expressions in the human has recently emerged. Two antagonistic interacting DA receptors or mechanisms have been demonstrated in the brain of the snail Helix aspersa, in the cat caudate nuclei, in the striatum-mesolimbic complex of rodents, and in the brain of rhesus monkey.
