ABSTRACT
Successful therapeutic approaches for physical and psychologic symptoms were outlined for more than 4000 nonpsychotic subjects, on the basis of their pharmacomanometric investigations. In a study carried out in institute, it was shown that only noradrenergic (NE) activity was present at the distal colon level in most psychotic patients, while only a small percentage of these patients showed dopamine (DA) activity exclusively. These findings seem to contradict the generally accepted hypothesis that postulates the existence of DA overactivity in schizophrenia. The NE-hyperactive patients fulfilled the Research Diagnostic Criteria of schizophrenia, whereas the DA-hyperactive patients were diagnosed as having schizoaffective disorders. NE-hyperactive subjects were successfully treated with clonidine, a drug which inhibits release of noradrenaline, while DA-hyperactive subjects were successfully treated with clonazepam, a drug which inhibits release of dopamine.
