Genital infections are severe public health problems worldwide, and infect 100 million women yearly at different ages. The most common infectious diseases of the female are vulvovaginal candidiasis, bacterial vaginosis, trichomoniasis, viral, and parasitic protozoan infections. Many vaginosis treatments are being used by doctors. The treatment protocol varies from the use of synthetic antibiotics to probiotics, the antimicrobial agents, and the antiseptics. The interest in phytopharmaceutical and herbal medicines has been a pattern in recent years, and this approach might be valuable as a reason for developing new control of these infectious diseases. Therefore, this chapter explores available information about vaginal infections and treatment with antibiotics, natural antimicrobials, plant-derived compounds, and health benefits.