In this paper, we made building taxonomy for Southeastern Tibet and estimated the distribution of different types of buildings in every town based on scientific investigation and census database in this area. We built structure vulnerability model and occupancy vulnerability model for each type of building, and compared our vulnerability models with parts of vulnerability models of buildings in Nepal in the research of Nepal’s seismic hazard and risk assessment. The comparison between our vulnerability models and Nepal ones shows that public and private houses in Southeastern Tibet have better seismic resistance than the concrete and UBM houses in Nepal. Old houses in Southeastern Tibet and Adobe houses in Nepal have similar vulnerability models, and vulnerability models of wood houses in both areas are also similar.