ABSTRACT
The pathogenesis of porcine polioencephalomyelitis appears to be comparable in most major respects to that of poliovirus infections in humans. In addition to neurological disease, porcine enteroviruses have been associated with other clinical syndromes, including diarrhea, pneumonia, pericarditis and myocarditis, exanthems, and antenatal and perinatal disease of pigs. The lesions histologically were those of a polioencephalomyelitis, and in the subsequent year the disease was found to be experimentally transmissible. The virulent strains associated with classical Teschen disease appear to be restricted to those geographical areas in which clinical disease occurs, and they have not been isolated in North America. Porcine enteroviruses resemble the enteroviruses of other species in their basic properties and are classified within the family Pi-cornaviradae. Porcine enteroviruses are readily grown in cell cultures of porcine origin. The oral route of infection is considered to be the principal natural route in porcine polioencephalomyelitis. Viremia follows regularly in virulent serogroup 1 viruses of porcine polioencephalomyelitis.
