ABSTRACT
This chapter highlights the development of notable approaches for the controlled delivery of therapeutic proteins. Proteins are structurally complex macro-biomolecules that are involved in a wide range of biological pathways in different forms, such as antibodies, hormones, enzymes, and interferons. Therapeutic proteins have proved their worth as emerging alternatives to cure various types of cancers, diabetes mellitus, and other serious, life-threatening ailments incurable by traditional therapeutic agents. On administration, therapeutic proteins play important roles at the cellular level and help to revive the normal physiological functions of the body. Matrix-type delivery systems help to achieve the controlled delivery of therapeutic proteins from parenteral formulations. Nanoparticles have proved their ability for a facile delivery of a range of drugs to their target sites for longer duration. Proteins suspended in organic solvent and polymeric solutions in an appropriate water-miscible organic solvent are used for injectable implants, and the protein-loaded implants are formed after in vivo injection.
